Functional impairment outcomes in clinical trials of different ADHD medications: post hoc responder analyses and baseline subgroup analyses
نویسندگان
چکیده
منابع مشابه
Considerations on Subgroup Analyses in Clinical Trials.
As clinicians, we routinely treat patients with drugs whose efficacy is supported by evidence from multicenter clinical trials, some of which include thousands of patients from different parts of the world. When it comes to treating a given patient, however, we need to know whether the beneficial effect described for the average patient will apply to this patient in particular. This can be done...
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I read with interest the European–Middle East Orgalutran trial (The European Orgalutran Study Group et al., 2000) and I noticed that the study extensively monitored hormonal assays (LH, FSH, oestradiol). It is well known that sufficient stimulation of both theca cells and granulosa cells by LH and FSH is required for adequate oestradiol biosynthesis (Short, 1962; Schoot et al., 1992) and hence ...
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Medical research relies on clinical trials to assess therapeutic benefits. Because of the effort and cost involved in these studies, investigators frequently use analyses of subgroups of study participants to extract as much information as possible. Such analyses, which assess the heterogeneity of treatment effects in subgroups of patients, may provide useful information for the care of patient...
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Subgroup analyses are commonly performed in the clinical trial setting with the purpose of illustrating that the treatment effect was consistent across different patient characteristics or identifying characteristics that should be targeted for treatment. There are statistical issues involved in performing subgroup analyses, however. These have been given considerable attention in the literatur...
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Subgroup analyses of major randomized clinical trials in heart failure are published frequently, but their impact on medical knowledge and practice guidelines has not been previously reported. In a novel analysis, we determined number of citations, impact factors, number of authors, and citations in guidelines of both parent trials and sub-studies; we also qualitatively assessed whether the ana...
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ژورنال
عنوان ژورنال: European Child & Adolescent Psychiatry
سال: 2020
ISSN: 1018-8827,1435-165X
DOI: 10.1007/s00787-020-01586-5